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Ten-year outcome: patients with schizoaffective disorders, schizophrenia, affective disorders and mood-incongruent psychotic symptoms.

Br J Psychiatry. 2000; 177:421-6 (ISSN: 0007-1250)

Harrow M; Grossman LS; Herbener ES; Davies EW
Department of Psychiatry, University of Illinois College of Medicine, Chicago, IL, USA.

BACKGROUND: It is unclear whether outcome in schizoaffective disorders is more similar to schizophrenia or affective disorders. AIMS: To provide longitudinal data on clinical course and outcome in schizoaffective disorders versus schizophrenia and affective disorders, and determine whether mood-incongruent psychotic symptoms have negative prognostic implications. METHOD: A total of 210 patients with schizoaffective disorders, schizophrenia, bipolar manic disorders and depression were assessed at hospitalisation and then followed up four times over 10 years. RESULTS: At all four follow-ups, fewer patients with schizoaffective disorders than with schizophrenia showed uniformly poor outcome. Patients with mood-incongruent psychotic symptoms during index hospitalisation showed significantly poorer subsequent outcome (P < 0.05). CONCLUSIONS: Schizoaffective outcome was better than schizophrenic outcome and poorer than outcome for psychotic affective disorders. Mood-incongruent psychotic symptoms have negative prognostic implications. The results could fit a symptom dimension view of schizoaffective course.

Major Subject Heading(s)	Minor Subject Heading(s)
	Acute Disease Adult Affective Disorders, Psychotic [diagnosis] [drug therapy] [rehabilitation] Analysis of Variance Female Follow-Up Studies Hospitalization [statistics & numerical data] Humans Male Patient Readmission [statistics & numerical data] Prognosis Prospective Studies Psychotic Disorders [diagnosis] [drug therapy] [rehabilitation] Schizophrenia [diagnosis] [drug therapy] [rehabilitation] Treatment Outcome

Major Subject Heading(s)

Minor Subject Heading(s)

Acute Disease
Adult
Affective Disorders, Psychotic [diagnosis] [drug therapy] [rehabilitation]
Analysis of Variance
Female
Follow-Up Studies
Hospitalization [statistics & numerical data]
Humans
Male
Patient Readmission [statistics & numerical data]
Prognosis
Prospective Studies
Psychotic Disorders [diagnosis] [drug therapy] [rehabilitation]
Schizophrenia [diagnosis] [drug therapy] [rehabilitation]
Treatment Outcome

PreMedline Identifier: 11059995

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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