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| * NBME form 2,block 1,question 1 |
| | #572705 |
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Anybody know what is Neuclear factor kappa B?
and what is its rule in septic shock? |
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| * Re:NBME form 2,block 1,question 1 |
| #2348376 |
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Neuclear factor kappa B is a transcription factor.
Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.
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| * Re:NBME form 2,block 1,question 1 |
| #2348377 |
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*Lipopolysacharides(Bacteria)
LPS bind to "Toll-like receptor"(TLR) (a single Transmembrane receptor)------> activation of Inhibitory kappa B kinase (IKB kinase)------->
Note: NF-kB is a transcription Factor that exist in cytoplasm bound to Inhibitory kappa B (IKB) protein in Inactive form [NF-kB=IKB]
so continuing the above sequence ..
LPS----> TLR---->+IKB kinase----->phosphorylation of IKB of the complex[NF-kB=IKB] and now this phosphorylated IKB get degraded and NF-kB is released----->NF-kB move to Nucleus where it upregulate gene expression of TNF------>Sepsis
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