Neuclear factor kappa B is a transcription factor.
Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.
LPS bind to "Toll-like receptor"(TLR) (a single Transmembrane receptor)------> activation of Inhibitory kappa B kinase (IKB kinase)------->
Note: NF-kB is a transcription Factor that exist in cytoplasm bound to Inhibitory kappa B (IKB) protein in Inactive form [NF-kB=IKB]
so continuing the above sequence ..
LPS----> TLR---->+IKB kinase----->phosphorylation of IKB of the complex[NF-kB=IKB] and now this phosphorylated IKB get degraded and NF-kB is released----->NF-kB move to Nucleus where it upregulate gene expression of TNF------>Sepsis